Calvarial Defect Healing Induced by Small Molecule Smoothened Agonist
نویسندگان
چکیده
منابع مشابه
Small molecule modulation of Smoothened activity.
Smoothened (Smo), a distant relative of G protein-coupled receptors, mediates Hedgehog (Hh) signaling during embryonic development and can initiate or transmit ligand-independent pathway activation in tumorigenesis. Although the cellular mechanisms that regulate Smo function remain unclear, the direct inhibition of Smo by cyclopamine, a plant-derived steroidal alkaloid, suggests that endogenous...
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Vertebrate Hedgehog (Hh) signals involved in development and some forms of cancer, such as basal cell carcinoma, are transduced by the primary cilium, a microtubular projection found on many cells. A critical step in vertebrate Hh signal transduction is the regulated movement of Smoothened (Smo), a seven-transmembrane protein, to the primary cilium. To identify small molecules that interfere wi...
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ژورنال
عنوان ژورنال: Tissue Engineering Part A
سال: 2016
ISSN: 1937-3341,1937-335X
DOI: 10.1089/ten.tea.2016.0167